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Monday, August 3, 2020 | History

5 edition of Rational anti-epileptic drug therapy found in the catalog.

Rational anti-epileptic drug therapy

by Pieter J. M. Guelen

  • 97 Want to read
  • 28 Currently reading

Published by Elsevier/North-Holland Biomedical Press, sole distributors for the USA and Canada, Elsevier/North-Holland in Amsterdam, New York, New York .
Written in English

    Subjects:
  • Epilepsy -- Chemotherapy.,
  • Anticonvulsants.

  • Edition Notes

    StatementPieter J. M. Guelen and Eppo van der Kleijn ; studies performed in close collaboration with Svein I. Johannessen, Bert F. Blom, Tom B. Vree.
    ContributionsKleijn, Eppo van der, joint author.
    Classifications
    LC ClassificationsRC374.C48 G83
    The Physical Object
    Paginationix, 182 p. :
    Number of Pages182
    ID Numbers
    Open LibraryOL4724690M
    ISBN 100444800778
    LC Control Number78012314
    OCLC/WorldCa4494985

    Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and. Antiepileptic Drug Interactions: A Clinical Guide, Second Edition should help physicians make more rational choices when polytherapy regimens are indicated and should be of interest to all who treat patients with epilepsy: neurologists and neurosurgeons, trainees at all levels, general practitioners and epilepsy nurse s: 1.

    The first 8 chapters review general concepts and substantial facts about epilepsy and antiepileptic drugs. The next 22 chapters are devoted to optimal therapy for individual underlying medical conditions or for particular adverse effects. Overall, the structure of the book and the list of chapters have remained unchanged from the first edition.   Epilepsy is a chronic disease that may require antiepileptic drug (AED) therapy for many years. The efficacy of AED monotherapy in the treatment of epilepsy is well established imately 60–70% of newly diagnosed patients will have their seizures controlled effectively by one AED, and switching to an alternative AED will offer effective seizure control in up to half of the remaining

    Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug–target network (EDT) is constructed and successfully demonstrates the. Explore the latest full-text research PDFs, articles, conference papers, preprints and more on ANTI-EPILEPTIC DRUGS. Find methods information, sources, references or conduct a literature review on.


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Rational anti-epileptic drug therapy by Pieter J. M. Guelen Download PDF EPUB FB2

Antiepileptic drug (AED) therapy starts with an accurate diagnosis of epilepsy and is followed by sequential drug trials. Seizure freedom is largely achieved by the first two drug trials; thus, Rational anti-epileptic drug therapy book that cannot be controlled after appropriately conducted trials of the first two drugs is defined as drug-resistant epilepsy (DRE).Cited by: 6.

Rational Rational anti-epileptic drug therapy book drug therapy Hardcover – January 1, by Pieter J. M Guelen (Author) › Visit Amazon's Pieter J.

M Guelen Page. Find all the books, read about the author, and more. See search results for this author. Are you an author. Learn about Author Central.

Pieter J Author: Pieter J. M Guelen. Rational anti-epileptic drug therapy. Amsterdam ; New York: Elsevier/North-Holland Biomedical Press ; New York: Sole distributors for the USA and Canada, Elsevier/North-Holland, (OCoLC) Online version: Guelen, Pieter J.M.

Rational anti-epileptic drug therapy. A Rational Antiepileptic Drug Therapy of Epileptic Women in Child Bearing Age. Sunao Kaneko M.D. Corresponding Author. Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki before the onset of pregnancy by decreasing the dose of the drug and/or changing from a combination of AEDs to a single drug.

Thus, the Cited by: 2. Keywords:Epilepsy, Antiepileptic drugs, Rational polytherapy, Drug combinations, Mechanisms of action, Pharmacokinetic interactions.

Abstract:When monotherapy for epilepsy fails, add-on therapy is an alternative option. There are several possible antiepileptic drug combinations based on their different and multiple mechanisms of action and. Antiepileptic drugs: combination therapy and interactions | Jerzy Majkowski,NetLibrary, Inc.

| download | B–OK. Download books for free. Find books. The situation regarding clinical evidence in support of “rational polytherapy” is similarly sparse, 68, 69 There are claims in the literature supporting particular efficacy for combinations including a sodium channel blocker with a GABA-ergic drug 56 or one with multiple mechanisms of action.

70 However, once again the only supportive evidence for synergism is with sodium valproate. An early attempt at rational polytherapy was the 19 th century combination therapy nervine (a mixture of bromide, arsenic, and picrotoxin); later, co-therapy with phenytoin and phenobarbital was commonly used for new-onset epilepsy during much of the 20 th century [10,30,74].

Rational polytherapy is a logical concept, since the pathophysiology. This new book, The Epilepsies, details the most recent advances in epileptic seizures, epileptic syndromes and their management. It is based on the International League Against Epilepsy (ILAE) classification, and practice parameter and guidelines issued by the ILAE and other recognised medical authorities.

Seizures and syndromes are explored in their scientific context and also include newly. Seizure control in children using anti-epileptic drug therapy.

Children using multi AEDs had a higher number of daily seizures compared to children on mono therapy. Children on multi AED were also less likely to have attained good seizure control (p.

A practical reference to the medical and surgical treatment of epilepsy. The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy.

Request PDF | Rational combination therapy in epilepsy. Clinical and pharmacological aspects | From an analysis of the studies published to date, the criteria used to select the antiepileptic.

Home > - Volume 1 - Issue 3 > Rational Antiepileptic Drug Therapy. Log in to view full text. If you're not a subscriber, you can: You can read the full text of this article if you: Select an option -- BOOK REVIEW: PDF Only.

Buy. I have been hearing about "rational polytherapy"; in other words, mixing antiepileptic drugs that have different mechanisms of action, as opposed to using a combination of drugs with more or less. Blood tests are often checked before starting an antiepileptic drug (AED).

Blood tests may be done again after you have been taking the seizure medicine for a while, especially if there’s been a change in dose or if you have a change in how you feel.

What do the blood tests measure. Blood tests may be done to check how much medicine is in your body, usually called drug or AED.

Keywords:Epilepsy, epileptogenesis, cell therapy, gene therapy, GABA, adenosine, galanin, neuropeptide Y. Abstract: Despite recent advances in the development of antiepileptic drugs, refractory epilepsy remains a major clinical problem affecting up to 35% of patients with partial epilepsy.

Currently, there are few therapies that affect the. Margolis JM, Chu B-C, Wang ZJ, Copher R, Cavazos JE. JAMA Neurol ; 71 (8)– []. IMPORTANCE: To our knowledge, the current study is the first to describe antiepileptic drug (AED) combination therapy patterns according to their mechanism of action (MOA) in a real-world setting and to evaluate the differences in outcomes comparing different-MOA combination therapy with same-MOA.

Breastfeeding Breastfeeding a newborn baby has many advantages, including improving the baby's health (important antibodies are present in breastmilk that are good for the baby!). Breastfeeding also helps the mother and baby bond during the early months. In addition, for many women, breastfeeding is an integral and important part of the experience of motherhood.

This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination s: 1.

For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs. 3. Does mechanism of action predict antiepileptic drug efficacy or side effects?

Animal models of seizures, epilepsy, and drug-related neurotoxicity are widely used in the identification of novel antiseizure agents, and many of them have been in routine laboratory use for er, these models offer an opportunity to characterize the efficacy and toxicity of single drugs and.The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community.

Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory.Consider potential drug interactions when starting combination therapy with antiepileptic drugs, Drugs & Therapy Perspectives, /sz, 34, 8, (), ().

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